HCID 18461257, compound → HCID 86758451, compound

HRID 2303817Notes

Reaction equation

HRID 2303817 reaction equation
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:42]=[CH:41][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([OH:31])[CH:26]=4)=[CH:20][C:19]=3[N:32]([CH3:40])C(=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1.[ClH:43].O1CCOCC1>>[ClH:43].[OH:31][C:27]1[CH:26]=[C:25]([CH:30]=[CH:29][CH:28]=1)[O:24][C:21]1[CH:22]=[CH:23][C:18]2[N:17]=[C:15]([CH2:14][O:13][C:12]3[CH:11]=[CH:10][C:9]([CH2:8][CH:4]4[S:3][C:2](=[O:1])[NH:6][C:5]4=[O:7])=[CH:42][CH:41]=3)[N:32]([CH3:40])[C:19]=2[CH:20]=1

Participants

3

Reactant 2

HCID 18461257HCID 18461257, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 86758451HCID 86758451, compound

Procedure

A mixture of t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-(3-hydroxyphenoxy)phenyl}-N-methylcarbamate (1.18 g) and 4N hydrogen chloride/dioxane (20 ml) was allowed to stand at ambient temperature for 18 hours. The solvent of the reaction mixture was evaporated to dryness. To the residue was added ethyl acetate and the mixture was irradiated by ultrasonic waves. The insoluble product was isolated by filtration and washed with ethyl acetate to give the title compound (0.86 g).

Workup

  1. customThe solvent of the reaction mixture was evaporated to dryness
  2. additionTo the residue was added ethyl acetate
  3. customthe mixture was irradiated by ultrasonic waves
  4. customThe insoluble product was isolated by filtration
  5. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-99345a0f9fdc4cef84a4eb4d2bca2cb0
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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