Hydrogen chloride-ethyl acetate → HCID 88008197, compound

HRID 2303822Notes

Reaction equation

HRID 2303822 reaction equation
[C:1]([C:5]1[CH:37]=[C:36]([OH:38])[C:35]([C:39]([CH3:42])([CH3:41])[CH3:40])=[CH:34][C:6]=1[O:7][C:8]1[CH:9]=[CH:10][C:11]2[N:15]=[C:14]([CH2:16][O:17][C:18]3[CH:31]=[CH:30][C:21]([CH2:22][CH:23]4[S:27][C:26](=[O:28])[NH:25][C:24]4=[O:29])=[CH:20][CH:19]=3)[N:13]([CH3:32])[C:12]=2[CH:33]=1)([CH3:4])([CH3:3])[CH3:2].[ClH:43].C(OCC)(=O)C>>[ClH:43].[C:1]([C:5]1[CH:37]=[C:36]([OH:38])[C:35]([C:39]([CH3:42])([CH3:41])[CH3:40])=[CH:34][C:6]=1[O:7][C:8]1[CH:9]=[CH:10][C:11]2[N:15]=[C:14]([CH2:16][O:17][C:18]3[CH:31]=[CH:30][C:21]([CH2:22][CH:23]4[S:27][C:26](=[O:28])[NH:25][C:24]4=[O:29])=[CH:20][CH:19]=3)[N:13]([CH3:32])[C:12]=2[CH:33]=1)([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 77844653HCID 77844653, compound

Product 1

HCID 88008197HCID 88008197, compound

Procedure

In a similar manner to that described in Example (2-2b), a reaction was carried out using 5-{4-[6-(2,5-di-t-butyl-4-hydroxyphenoxy)-1-methyl-1H-benzimidazole-2-ylmethoxy]benzyl}thiazolidine-2,4-dione (0.73 g) and 4N hydrogen chloride/ethyl acetate (20 ml) and the reaction mixture was purified to give the title compound (0.31 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-7ddd861a82454019be25365636cb3eea
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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