HCID 18461326, compound → 5-[4-[6-(4-aminophenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione dihydrochloride

Participants

Reaction Steps

A mixture of a solution of t-butyl N-{5-(4-aminophenoxy)-2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]phenyl}-N-methylcarbamate (27.08 g) in 1,4-dioxane (50 ml) and 4N hydrogen chloride/dioxane (150 ml) was stirred at ambient temperature for 2 days. The insoluble product was isolated by filtration and washed with ethyl acetate to give the title compound (14.43 g).

Provenance & Evidence