HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 10281712, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pyridine-4-carbonyl chloride | HCID 417436 | — |
| Reactant | 5-[4-[6-(4-aminophenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione dihydrochloride | HCID 86587768 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 10281712 | HCID 10281712 | 72.3% |
Reaction Steps
In a similar manner to that described in Example 47, a reaction was carried out using 5-{4-[6-(4-aminophenoxy)-1-methyl-1H-benzimidazole-2-ylmethoxy]benzyl}thiazolidine-2,4-dione dihydrochloride (400 mg), isonicotinoylchloride (142 mg), triethylamine (232 mg) and anhydrous N,N-dimethylformamide (8 ml) and the reaction mixture was purified to give the title compound (306 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432993B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-47edb09f475c41988d52af064d211c3e |
| Source note | uspto-grants-2002_08 |