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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2303832Generated: November 1, 2026

Triethylamine → HCID 18537619, compound

https://huagongshe.com/reaction/2303832

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethylamineHCID 8471—
Reactant2,4-Difluorobenzoyl chlorideHCID 588081—
Reactant5-[4-[6-(4-aminophenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione dihydrochlorideHCID 86587768—
SolventDimethylformamideHCID 6228—
ProductHCID 18537619HCID 1853761955.9%

Reaction Steps

In a similar manner to that described in Example 47, a reaction was carried out using 5-{4-[6-(4-aminophenoxy)-1-methyl-1H-benzimidazole-2-ylmethoxy]benzyl}thiazolidine-2,4-dione dihydrochloride (400 mg), 2,4-difluorobenzoylchloride (141 mg), triethylamine (232 mg) and anhydrous N,N-dimethylformamide (8 ml) and the reaction mixture was purified to give the title compound (251 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06432993B1
Source datasetuspto-grants-2002_08
ORD IDord-213f8a704c2944a58de39bda529a1b2d
Source noteuspto-grants-2002_08