反应详情

8.09 g of crude 4-methoxymethoxy-3,5-dimethylphenyl pivaloate were dissolved in 30 ml of methanol. To the resulting solution, 30 ml of a solution of 3.40 g of potassium hydroxide in methanol were added dropwise, followed by stirring at room temperature for 4 hours. The reaction mixture was concentrated by evaporation. Water was added to the residue. The mixture was neutralized with 3N hydrochloric acid and sodium bicarbonate, followed by extraction with ethyl acetate. The extract was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The residue was purified by chromatography through a silica gel column (eluting solvent: n-hexane/ethyl acetate=4/1), whereby 5.58 g of the title compound were obtained.

1. concentrationThe reaction mixture was concentrated by evaporation
2. additionWater was added to the residue
3. extractionfollowed by extraction with ethyl acetate
4. dry with materialThe extract was dried over anhydrous sodium sulfate
5. distillationThe solvent was distilled off under reduced pressure
6. customThe residue was purified by chromatography through a silica gel column (eluting solvent: n-hexane/ethyl acetate=4/1)