HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → t-Butyl N-[5-(3,5-di-t-butyl-4-hydroxyphenylthio)-2-nitrophenyl]-N-methylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,6-Di-tert-butyl-4-mercaptophenol | HCID 70370 | — |
| Reactant | tert-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate | HCID 15544598 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | t-Butyl N-[5-(3,5-di-t-butyl-4-hydroxyphenylthio)-2-nitrophenyl]-N-methylcarbamate | HCID 18184967 | 38% |
Reaction Steps
By using 476 mg of 3,5-di-t-butyl-4-hydroxybenzenethiol, 573 mg of t-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate, 175 mg of sodium hydride (55% by weight) and 10 ml of anhydrous N,N-dimethylformamide, reaction and purification were carried out in a similar manner to that described in Reference Example 6, whereby 371 mg of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432993B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-5b55bb756c4b4212ac63461e7fe71f38 |
| Source note | uspto-grants-2002_08 |