HCID 18461493, compound → HCID 18461429, compound

HRID 2303858Notes

Reaction equation

HRID 2303858 reaction equation
[N:1]1([C:7]2[CH:31]=[CH:30][CH:29]=[CH:28][C:8]=2[O:9][C:10]2[CH:11]=[CH:12][C:13]([N+:25]([O-])=O)=[C:14]([N:16]([CH3:24])[C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH:15]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>[Pd].CO>[NH2:25][C:13]1[CH:12]=[CH:11][C:10]([O:9][C:8]2[CH:28]=[CH:29][CH:30]=[CH:31][C:7]=2[N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[CH:15][C:14]=1[N:16]([CH3:24])[C:17](=[O:23])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22]

Participants

4

Reactant 1

HCID 18461493HCID 18461493, compound

Product 1

HCID 18461429HCID 18461429, compoundYield 89.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

By using 1.44 g of t-butyl N-{5-[2-(morpholin-4-yl)phenoxy]-2-nitrophenyl}-N-methylcarbamate, 0.20 g of 10% palladium on carbon and 50 ml of methanol, reaction and purification were carried out in a similar manner to Reference Example 7, whereby 1.20 g of the title compound was obtained.

Sources & evidence

ORD record
ord-9fee79872201463eb01bdd5d8f22a87c
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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