HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Dimethylamino)phenol → t-Butyl N-[5-(3-dimethylaminophenoxy)-2-nitrophenyl]-N-methylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Dimethylamino)phenol | HCID 7421 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | tert-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate | HCID 15544598 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | t-Butyl N-[5-(3-dimethylaminophenoxy)-2-nitrophenyl]-N-methylcarbamate | HCID 18461334 | 93.7% |
Reaction Steps
In a similar manner to that described in Reference Example 6, a reaction was carried out using 3-dimethylaminophenol (0.82 g), t-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate (1.72 g), sodium hydride (55 wt. %, 0.26 g) and anhydrous N,N-dimethylformamide (50 ml) and the reaction mixture was purified to give the title compound (2.17 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432993B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-36aa7ddd0eba43589552a39220082e61 |
| Source note | uspto-grants-2002_08 |