HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 18461327, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(p-Hydroxyphenyl)imidazole | HCID 82315 | — |
| Reactant | tert-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate | HCID 15544598 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18461327 | HCID 18461327 | 83.8% |
Reaction Steps
In a similar manner to that described in Reference Example 6, a reaction was carried out using 4-(imidazol-1-yl)phenol (4.1 g), t-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate (7.85 g), sodium hydride (55 wt. %, 1.25 g) and anhydrous N,N-dimethylformamide (45 ml) and the reaction mixture was purified to give the title compound (8.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432993B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-95df7835b69a4d2da42653cb5a6853c0 |
| Source note | uspto-grants-2002_08 |