Cyclohexanone → HCID 178443966, compound

HRID 230387Notes

Reaction equation

HRID 230387 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH:13]([NH2:20])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[NH:11][CH:12]=2)=[CH:4][CH:3]=1.[C:21]1(=O)[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([CH:13]([NH:20][CH:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[NH:11][CH:12]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 7967CyclohexanoneHCID 178443969HCID 178443969, compound

Product 1

HCID 178443966HCID 178443966, compoundYield 15%

Procedure

This compound was obtained according to a protocol analogous to that of stage 13777.4 of example 13777, using 1-(4-(4-fluorophenyl)-1H-imidazol-2-yl)-1-heptanamine (0.5 g; 0.0014 mol) as starting amine and cyclohexanone (0.17 ml; 0.0014 mol) as starting ketone. A white powder was obtained with a yield of 15%. Melting point: 190-192° C. MH+=358.2.

Workup

  1. customThis compound was obtained
  2. customA white powder was obtained with a yield of 15%

Sources & evidence

ORD record
ord-017e9ab23fdc43138036d7b22c07757a
Source dataset
uspto-grants-2009_07
Patent number
US07566734B2

Reaction notes

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