Tert-Butylhydroquinone → HCID 18461476, compound

Participants

Reaction Steps

In a similar manner to that described in Reference Example 6 a reaction was carried out using t-butylhydroquinone (1.66 g), t-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate (2.87 g), sodium hydride (55 wt. %, 0.87 g) and anhydrous N,N-dimethylformamide (20 ml) and the reaction mixture was purified by chromatography on a silica gel column using n-hexane/ethyl acetate=4/1 to give t-butyl N-[5-(3-t-butyl-4-hydroxyphenoxy)-2-nitrophenyl]-N-methylcarbamate (1.35 g), of which Rf value was 0.45 in thin layer chromatography on a silica gel plate using n-hexane/ethyl acetate=3/1 and t-butyl N-[5-(2-t-butyl-4-hydroxyphenoxy)-2-nitrophenyl]-N-methylcarbamate (1.11 g), of which Rf value was 0.35 in thin layer chromatography on a silica gel plate using n-hexane/ethyl acetate=3/1.

Provenance & Evidence