Sodium hydride → t-Butyl N-[5-(4'-benzyloxybiphenyl-4-yloxy)-2-nitrophenyl]-N-methylcarbamate

Participants

Reaction Steps

In a similar manner to that described in Reference Example 6, a reaction was carried out using 4′-benzyloxybiphenyl-4-ol (11.07 g), t-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate (11.5 g), sodium hydride (55 wt. %, 2.2 g) and anhydrous N,N-dimethylformamide/anhydrous tetrahydrofuran/anhydrous toluene=1/1/1 (360 ml) and the reaction mixture was purified to give the title compound (14.75 g).

Provenance & Evidence