HCID 18461370, compound → HCID 18461283, compound

HRID 2303881Notes

Reaction equation

HRID 2303881 reaction equation
C([O:8][C:9]1[CH:33]=[CH:32][CH:31]=[CH:30][C:10]=1[O:11][C:12]1[CH:13]=[CH:14][C:15]([N+:27]([O-])=O)=[C:16]([N:18]([CH3:26])[C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH:17]=1)C1C=CC=CC=1>[Pd].CO>[NH2:27][C:15]1[CH:14]=[CH:13][C:12]([O:11][C:10]2[CH:30]=[CH:31][CH:32]=[CH:33][C:9]=2[OH:8])=[CH:17][C:16]=1[N:18]([CH3:26])[C:19](=[O:25])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24]

Participants

4

Reactant 1

HCID 18461370HCID 18461370, compound

Product 1

HCID 18461283HCID 18461283, compoundYield 95.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-[5-(2-benzyloxyphenoxy)-2-nitrophenyl]-N-methylcarbamate (4.14 g), palladium on carbon (10%, 0.41 g) and methanol (60 ml) and the reaction mixture was purified to give the title compound (2.89 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-51bdbf49630c45d38debb08e003a3665
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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