t-Butyl N-methyl-N-[2-nitro-5-(4-phenoxyphenoxy)phenyl]carbamate → t-Butyl N-[2-amino-5-(4-phenoxyphenoxy)phenyl]-N-methylcarbamate

Participants

Role	Name	HCID	Charge
Reactant	t-Butyl N-methyl-N-[2-nitro-5-(4-phenoxyphenoxy)phenyl]carbamate	HCID 18461359	—
Catalyst	Palladium	HCID 23938	—
Solvent	Toluene methanol	HCID 21867641	—
Product	t-Butyl N-[2-amino-5-(4-phenoxyphenoxy)phenyl]-N-methylcarbamate	HCID 18461416	89.9%

Reaction Steps

In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-[2-nitro-5-(4-phenoxyphenoxy)phenyl]-N-methylcarbamate (8.6 g), palladium on carbon (10%, 0.6 g) and toluene/methanol=16/3 (190 ml) and the reaction mixture was purified to give the title compound (7.2 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06432993B1
Source dataset	uspto-grants-2002_08
ORD ID	ord-25a871967099458cbe50b5eb1f201e18
Source note	uspto-grants-2002_08