HCID 18461477, compound → HCID 18461421, compound

HRID 2303890Notes

Reaction equation

HRID 2303890 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([CH:28]=[CH:29][C:30]=1[OH:31])[O:8][C:9]1[CH:10]=[CH:11][C:12]([N+:25]([O-])=O)=[C:13]([N:15]([CH2:23]C)[C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH:14]=1)([CH3:4])([CH3:3])[CH3:2]>[Pd].CO>[NH2:25][C:12]1[CH:11]=[CH:10][C:9]([O:8][C:7]2[CH:28]=[CH:29][C:30]([OH:31])=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[CH:6]=2)=[CH:14][C:13]=1[N:15]([CH3:23])[C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19]

Participants

4

Reactant 1

HCID 18461477HCID 18461477, compound

Product 1

HCID 18461421HCID 18461421, compoundYield 95.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-[5-(3-t-butyl-4-hydroxyphenoxy)-2-nitrophenyl]-N-ethylcarbamate (1.29 g), palladium on carbon (10%, 0.16 g) and methanol (40 ml) and the reaction mixture was purified to give the title compound (1.11 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-4bf7f93a2f5541d29c31e1addfcbe8dd
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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