HCID 18461420, compound → t-Butyl N-[2-amino-5-(2-t-butyl-4-hydroxyphenoxy)phenyl]-N-methylcarbamate

HRID 2303891Notes

Reaction equation

HRID 2303891 reaction equation
[C:1]([C:5]1[CH:29]=[C:28]([OH:30])[CH:27]=[CH:26][C:6]=1[O:7][C:8]1[CH:9]=[CH:10][C:11]([N+:23]([O-])=O)=[C:12]([N:14]([CH3:22])[C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH:13]=1)([CH3:4])([CH3:3])[CH3:2]>[Pd].CO>[NH2:23][C:11]1[CH:10]=[CH:9][C:8]([O:7][C:6]2[CH:26]=[CH:27][C:28]([OH:30])=[CH:29][C:5]=2[C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:13][C:12]=1[N:14]([CH3:22])[C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18]

Participants

4

Reactant 1

HCID 18461420HCID 18461420, compound

Product 1

HCID 18461458t-Butyl N-[2-amino-5-(2-t-butyl-4-hydroxyphenoxy)phenyl]-N-methylcarbamateYield 93.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-[5-(2-t-butyl-4-hydroxyphenoxy)-2-nitrophenyl]-N-methylcarbamate (1.09 g), palladium on carbon (10%, 0.15 g) and methanol (20 ml) and the reaction mixture was purified to give the title compound (0.95 g).

Workup

  1. customthe reaction mixture was purified

Sources & evidence

ORD record
ord-d9f6cf1d8ca946a1a38f5b9e3ce69c7f
Source dataset
uspto-grants-2002_08
Patent number
US06432993B1

Reaction notes

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