HuagongsheHuagongshe Chemistry Print Report · For research reference only
t-butyl N-[5-(4-hydroxy-2,5-dimethylphenoxy)-2-nitrophenyl]-N-methylcarbamate → t-Butyl N-[2-amino-5-(4-hydroxy-2,5-dimethylphenoxy)phenyl]-N-methylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | t-butyl N-[5-(4-hydroxy-2,5-dimethylphenoxy)-2-nitrophenyl]-N-methylcarbamate | HCID 18461383 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | t-Butyl N-[2-amino-5-(4-hydroxy-2,5-dimethylphenoxy)phenyl]-N-methylcarbamate | HCID 18461389 | 90.2% |
Reaction Steps
In a similar manner to that described in Reference Example 7, a reaction was carried out using t-butyl N-[5-(4-hydroxy-2,5-dimethylphenoxy)-2-nitrophenyl]-N-methylcarbamate (1.73 g), palladium on carbon (10%, 0.17 g) and methanol (50 ml) and the reaction mixture was purified to give the title compound (1.44 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432993B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-edc50d718fd64f559a577186742f0904 |
| Source note | uspto-grants-2002_08 |