HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → t-Butyl N-methyl-N-[2-nitro-5-(4-trifluoromethylphenoxy)phenyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(Trifluoromethyl)phenol | HCID 67874 | — |
| Reactant | tert-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate | HCID 15544598 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | t-Butyl N-methyl-N-[2-nitro-5-(4-trifluoromethylphenoxy)phenyl]carbamate | HCID 18461356 | 20.4% |
Reaction Steps
In a similar manner to that described in Reference Example 6, a reaction was carried out using 4-trifluoromethylphenol (3.0 g), t-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate (4.3 g), sodium hydride (55 wt. %, 1.1 g) and anhydrous N,N-dimethylformamide (70 ml) and the reaction mixture was purified to give the title compound (1.26 g)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432993B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-93127b3f3e694269b3285e610bb41ca7 |
| Source note | uspto-grants-2002_08 |