HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 18537685, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | N-Boc-4-hydroxyaniline | HCID 2756771 | — |
| Reactant | tert-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate | HCID 15544598 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18537685 | HCID 18537685 | 82.3% |
Reaction Steps
In a similar manner to that described in Reference Example 6, a reaction was carried out using t-butyl (4-hydroxyphenyl)carbamate (15.6 g), t-butyl N-(5-chloro-2-nitrophenyl)-N-methylcarbamate (21 g), sodium hydride (55 wt. %, 3.22 g) and anhydrous N,N-dimethylformamide (130 ml) and the reaction mixture was purified to give the title compound (27.7 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432993B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-f86c15d5224043fe979af3001431bd9c |
| Source note | uspto-grants-2002_08 |