Sodium Hydroxide → 3-Quinuclidinone

Participants

Reaction Steps

99% Sodium hydroxide (97.0 g, 2.4 mol) was dissolved in water (285 ml) and 3-quinuclidinone hydrochloride (193.9 g, 1.2 mol) was added. The mixture was extracted with toluene (600 ml). The obtained aqueous layer was re-extracted with toluene (300 ml). The obtained toluene layer was combined with the toluene layer obtained previously and the mixture was dried over anhydrous magnesium sulfate and concentrated to give a toluene solution (438.1 g) containing 3-quinuclidinone (150.2 g, yield: 100%).

Provenance & Evidence