Acetic Acid → HCID 15662541, compound

Participants

Reaction Steps

(E)-10-(1-Azabicyclo[2.2.2]oct-3-ylidenemethyl)phenothiazine (10.00 g, 0.0312 mol), acetic acid (2.25 g, 0.0374 mol) and 10% palladium carbon (2.00 g, water content 50%) were added to methanol (158 g) and the mixture was stirred under pressurization with hydrogen (3-5 kg/cm2, hydrogen gas amount:equimolar amount relative to starting material) at 45-50° C. for 8 hr. The obtained reaction mixture was subjected to HPLC. As a result, the starting material was not detected but highly pure mequitazine was quantitatively obtained.

Provenance & Evidence