Acetic Acid → HCID 15662541, compound

Participants

Reaction Steps

(E)-10-(1-Azabicyclo[2.2.2]oct-3-ylidenemethyl)phenothiazine (183.9 g, 0.574 mol), acetic acid (68.9 g, 1.15 mol) and 10% palladium carbon (37.0 g, water content 50%) were added to methanol (1290 ml) and the mixture was stirred under pressurization with hydrogen (3-5 kg/cm2, hydrogen gas amount: equimolar amount relative to starting material) at 45-50° C. for 8 hr. The obtained reaction mixture was subjected to HPLC. As a result, the starting material was not detected but highly pure mequitazine was quantitatively obtained. The 1H-NMR of the obtained compound was the same as in Example 18.

Provenance & Evidence