反应详情

To a stirred mixture of powdered potassium hydroxide in methyl sulfoxide is added dropwise a solution of 5-methoxyindole-3-carboxaldehyde in methyl sulfoxide. The mixture is stirred for 30 min and 1-bromo-4-chlorobutane is added dropwise. The mixture is stirred for 1 h and partitioned between ethyl acetate and water. The combined organic extracts are washed (water, brine), dried (sodium sulfate) and concentrated in vacuo to give the product.

1. stirringThe mixture is stirred for 1 h
2. custompartitioned between ethyl acetate and water
3. washThe combined organic extracts are washed (water, brine)
4. dry with materialdried (sodium sulfate)
5. concentrationconcentrated in vacuo
6. customto give the product