HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 5-Methoxy-1-(4-iodobutyl)indole-3-carboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | 5-Methoxy-1-(4-chlorobutyl)indole-3-carboxaldehyde | HCID 18462083 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5-Methoxy-1-(4-iodobutyl)indole-3-carboxaldehyde | HCID 18462069 | — |
Reaction Steps
A stirred solution of 5-methoxy-1-(4-chlorobutyl)indole-3-carboxaldehyde and sodium iodide in acetonitrile under argon is heated under reflux for 18 h, cooled to room temperature and partitioned between ether and water. The combined organic extracts are washed (aqueous sodium metabisulfite solution, water, brine), dried (sodium sulfate) and concentrated in vacuo to give the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06433175B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-98b5809d616445678b0704544d83cb45 |
| Source note | uspto-grants-2002_08 |