HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitroethane → 1-(2-Methoxy-6,7,8,9-tetrahydro-pyrido[1,2-a]indol-10-yl)-2-nitro-1-propene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitroethane | HCID 6587 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 2-Methoxy-6,7,8,9-tetrahydro-pyrido[1,2-a]indole-10-carboxaldehyde | HCID 18462080 | — |
| Product | 1-(2-Methoxy-6,7,8,9-tetrahydro-pyrido[1,2-a]indol-10-yl)-2-nitro-1-propene | HCID 69850643 | — |
Reaction Steps
A stirred solution of 2-methoxy-6,7,8,9-tetrahydro-pyrido[1,2-a]indole-10-carboxaldehyde and ammonium acetate in nitroethane is heated to 100° C. for 1 h, cooled to room temperature and partitioned between ethyl acetate and water. The combined organic extracts are washed (water, brine), dried (sodium sulfate) and concentrated in vacuo to give the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06433175B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-12b86162024f4182afcce83a0e8d7e35 |
| Source note | uspto-grants-2002_08 |