Potassium sodium tartarate → HCID 18462062, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of lithium aluminium hydride in tetrahydrofuran under argon is added dropwise a solution of 1-(2-methoxy-7,8,9,10-tetrahydro-6H-azepino[1,2-a]indol-11-yl)-2-nitro-1-propene in tetrahydrofuran. The mixture is heated under reflux for 4 h and cooled to 0° C. To the mixture is added dropwise aqueous potassium sodium tartrate solution and the mixture is stirred for 30 min and filtered through kieselguhr. The filtrate is extracted with dichloromethane. The combined organic extracts are washed (water, brine), dried (sodium sulfate), concentrated in vacuo, dissolved in hot 2-propanol and added dropwise to a stirred solution of fumaric acid in 2-propanol at 50° C. The mixture is cooled to 0° C. and filtered. The filter-cake is washed (2-propanol, ether) and dried to give the product.

Provenance & Evidence