1-Phenethylamine → HCID 86758413, compound

Participants

Reaction Conditions

Reaction Steps

1.21 g (10.0 mmol) of (−)-1-phenylethylamine and 25 ml of 1-propanol were added to 2.77 g (10.0 mmol) of (±)-3-(3,4-dichlorophenyl)-3-methoxycarbonylpropionic acid and dissolved by heating. Then the solution was cooled to an internal temperature of 90° C. and inoculated with the separately prepared seed crystals. The solution was then cooled to an internal temperature of 70 to 72° C. and stirred in a suspended state for 8 hours. Then the solution was further cooled to an internal temperature of 20° C. and stirred at this temperature for 0.5 hour, and the precipitated crystals were filtered out, washed with a small quantity of 1-propanol and dried to obtain 2.13 g (53.6% yield) of (+)-3-(3,4-dichlorophenyl)-3-methoxycarbonylpropionic acid·(S)-1-phenylethylamine salt.

Provenance & Evidence