1-Phenethylamine → HCID 86758413, compound

Participants

Reaction Conditions

Reaction Steps

1.22 g (10.1 mmol) of (−)-1-phenylethylamine, 0.0766 g (0.503 mmol) of 1,8-diazobicyclo[5.4.0]-undeca-7-ene (hereinafter abbreviated as DBU) and 23.9 ml of 2-propanol were added to 2.77 g (10.0 mmol) of (±)-3-(3,4-dichlorophenyl)-3-methoxycarbonylpropionic acid and heated until the internal temperature became 72° C. With this temperature maintained, the solution was stirred in a suspended state for 8 hours, then it was cooled to an internal temperature of 20° C. and further stirred at this temperature for 0.5 hour. The precipitated crystals were filtered out, washed with a small amount of 2-propanol and dried to obtain 3.37 g (84.7% yield) of (+)-3-(3,4-dichlorophenyl)-3-methoxycarbonylpropionic acid·(S)-1-phenylethylamine salt.

Provenance & Evidence