Hydrochloric Acid → HCID 15524254, compound

Participants

Reaction Steps

4.00 g (10.0 mmol) of (+)-3-(3,4-dichlorophenyl)-3-methoxycarbonylpropionic acid·(S)-1-phenylethylamine salt obtained in Example 24 was suspended in 12.0 ml of ethyl acetate and cooled with ice water. 12.1 ml of 1N hydrochloric acid was added thereto to decompose the salt and the organic layer was separated. The aqueous layer was extracted twice with 6.0 ml of ethyl acetate, then joined with the previously separated organic layer and washed with 10 ml each of 1N hydrochloric acid, water and a saturated saline solution (twice). The organic layer was dried over anhydrous sodium sulfate and the solvent was distilled away to obtain 2.77 g (99.4% yield) of (+)-3-(3,4-dichlorophenyl)-3-methoxycarbonylpropionic acid.

Provenance & Evidence