1-Phenethylamine, (-)- → HCID 86758414, compound

Participants

Reaction Conditions

Reaction Steps

176.60 g (0.500 mol) of 3-(3,4-dichlorophenyl)-3-benzyloxycarbonylpropionic acid was suspended in 1,250 ml of 2-propanol and the solution was heated to an internal temperature of 70° C. Then 60.59 g (0.500 mol) of (S)-1-phenylethylamine and 6.09 g (0.040 mol) of DBU were added and the solution was heated to an internal temperature of 75° C. and stirred. With this temperature maintained, the solution was further stirred for 3 hours, then cooled slowly to an internal temperature of 30° C. and additionally stirred at this temperature for 2 hours. The precipitated crystals were filtered by a Nutsche funnel and then washed thrice with 250 ml of 2-propanol to obtain 177.40 g (72.9% yield) of (+)-3-(3,4-dichlorophenyl)-3-benzyloxycarbonylpropionic acid·(S)-1-phenylethylamine salt.

Provenance & Evidence