1,4-Dicyanobenzene → p-Cyanobenzamide
Reaction equation
[C:1](#[N:10])[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[OH-:11].[Na+]>C(O)(CC)C>[C:6]([C:5]1[CH:8]=[CH:9][C:2]([C:1]([NH2:10])=[O:11])=[CH:3][CH:4]=1)#[N:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Terephthalonitrile (12.8 g, 0.1 mol) and sec-butanol (243.2 g) were mixed, and the resultant mixture was heated to 80° C. with stirring. To the mixture, a 20% aqueous solution of sodium hydroxide (4 g) was added over three hours. Liquid chromatographic analysis revealed the reaction mixture contained 10.7 g of p-cyanobenzamide (yield 73%).
Sources & evidence
- ORD record
- ord-e0cd683c59874c5e8ef1dac93ed1e29e
- Source dataset
- uspto-grants-2002_08
- Patent number
- US06433211B1
Reaction notes
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