HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitrogen trioxide → 3-Cyanobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitrogen trioxide | HCID 61526 | — |
| Reactant | 3-Cyanobenzamide | HCID 76974 | — |
| Reactant | 16-(Acetyloxy)-3-((2,6-dideoxyhexopyranosyl-(1->4)-2,6-dideoxyhexopyranosyl-(1->4)-2,6-dideoxyhexopyranosyl)oxy)-14-hydroxycard-20(22)-enolide | HCID 93049 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 3-Cyanobenzoic acid | HCID 15875 | 92% |
Reaction Steps
m-Cyanobenzamide (2.92 g) was added to a 70 wt. % aqueous sulfuric acid solution (100 ml), and the mixture was stirred under cooling with ice. The mixture was allowed to react while dinitrogen trioxide gas was introduced thereto at 336 N ml/hour for two hours. The precipitated crystals were collected through filtration, washed with water, and dried, to thereby obtain 2.68 g of m-cyanobenzoic acid (yield 92%, based on m-cyanobenzamide). The m-cyanobenzoic acid obtained had a purity of 99% or more.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06433211B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-e266a14b7a464cd5baa627aba10816d2 |
| Source note | uspto-grants-2002_08 |