反应详情

Acetic acid (30 ml), acetic anhydride (70 ml), sodium acetate (6.2 g), and m-cyanobenzamide (5.0 g) were mixed with stirring under cooling with ice, to thereby obtain a mixture. The mixture was allowed to react while the mixed gas of nitrogen monoxide and nitrogen dioxide (volume ratio 1:1) was introduced thereto at 286 N ml/minute for four hours. The residual solvent was removed through distillation in vacuum, and water was added to the residue, to thereby form crystals. The precipitated crystals were collected through filtration, washed with water, and dried, to thereby obtain 4.78 g of m-cyanobenzoic acid (yield 94%, based on m-cyanobenzamide). The m-cyanobenzoic acid obtained had a purity of 98%.

1. temperatureunder cooling with ice
2. customto thereby obtain a mixture
3. additionwas introduced
4. customThe residual solvent was removed through distillation in vacuum, and water
5. additionwas added to the residue
6. customto thereby form crystals
7. filtrationThe precipitated crystals were collected through filtration
8. washwashed with water
9. customdried