Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ethyl 4-cyanobenzoate | HCID 81589 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Cyanobenzoic acid | HCID 12087 | 92% |
Reaction Steps
A mixture containing ethyl p-cyanobenzoate (87.5 g, 0.5 mol), ethanol (192.5 g), and water (449.2 g) was placed in a 1 l-flask. The mixture was heated to 82° C., and sodium hydrogencarbonate was added thereto so as to adjust the pH of the mixture at 9.0-9.3. Seven hours after the reaction started, liquid chromatographic analysis revealed that the reaction mixture contained 67.6 g of p-cyanobenzoic acid (yield 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06433211B1 |
|---|
| Source dataset | uspto-grants-2002_08 |
|---|
| ORD ID | ord-f826a29cb8ea4281b3188463e42c14f1 |
|---|
| Source note | uspto-grants-2002_08 |
|---|
