Maleic Acid → Fluvoxamine maleate

HRID 2304107Notes

Reaction equation

HRID 2304107 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6]/[C:7](/[C:13]1[CH:14]=[CH:15][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:18]=1)=[N:8]\[O:9][CH2:10][CH2:11][NH2:12].[C:23]([OH:30])(=[O:29])/[CH:24]=[CH:25]\[C:26]([OH:28])=[O:27]>O>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6]/[C:7](/[C:13]1[CH:14]=[CH:15][C:16]([C:19]([F:20])([F:22])[F:21])=[CH:17][CH:18]=1)=[N:8]\[O:9][CH2:10][CH2:11][NH2:12].[CH:24](/[C:23]([OH:30])=[O:29])=[CH:25]/[C:26]([OH:28])=[O:27]

Participants

4

Reactant 2

HCID 444266Maleic AcidHCID 5324346Fluvoxamine

Product 1

HCID 9560989Fluvoxamine maleate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

treating the organic layer containing fluvoxamine base with a solution of maleic acid in a protic solvent or water to obtain fluvoxamine maleate; and

Workup

  1. additiontreating the organic layer

Sources & evidence

ORD record
ord-df0d3d3cfb1b4890af869c2c122ee683
Source dataset
uspto-grants-2002_08
Patent number
US06433225B1

Reaction notes

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