7-Bromo-1-Chloroisoquinoline → 7-Bromo-1-phenoxyisoquinoline

HRID 2304243Notes

Reaction equation

HRID 2304243 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2Cl)=[CH:4][CH:3]=1.BrC1C=C2C(=CC=1)C([O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=NC=C2>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2[O:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 65020247-Bromo-1-ChloroisoquinolineHCID 226658626-Bromo-1-phenoxyisoquinoline

Product 1

HCID 226658407-Bromo-1-phenoxyisoquinoline

Procedure

Compound 37c was prepared from 37b using the procedure described for 1c. 1H-NMR 200 MHz (CDCl3) δ: 6.76-6.97 (2H, m), 7.18-8.09 (7H, m), 8.60-8.64 (1H, m).

Sources & evidence

ORD record
ord-4f192a2d7cca422ea53682ee9c5b6538
Source dataset
uspto-grants-2002_08
Patent number
US06432955B1

Reaction notes

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