N-(6-formyl-1-isoquinolinyl)benzamide → N-(7-Formylisoquinolinyl)benzamide

HRID 2304245Notes

Reaction equation

HRID 2304245 reaction equation
Br[C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2[NH:12][C:13](=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:4][CH:3]=1.[CH:21](C1C=C2C(=CC=1)C(NC(=O)C1C=CC=CC=1)=NC=C2)=[O:22]>>[CH:21]([C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2[NH:12][C:13](=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:4][CH:3]=1)=[O:22]

Participants

3

Reactant 2

HCID 22665740N-(6-formyl-1-isoquinolinyl)benzamideHCID 22665843N-(7-bromo-1-isoquinolinyl)benzamide

Product 1

HCID 22665912N-(7-Formylisoquinolinyl)benzamide

Procedure

N-(7-Formylisoquinolinyl)benzamide was prepared from 37e using the procedure described for 1f but was not purified using column chromatography. The crude aldehyde was transformed into the title compound using the procedure described for 1g followed by purification using column chromatography on silica gel (toluene/ethyl acetate: 2/1). M.p. 137.5-139.0° C.

Workup

  1. customwas not purified
  2. customfollowed by purification

Sources & evidence

ORD record
ord-6aa9ecf518b34de3a22fe304c686f9ae
Source dataset
uspto-grants-2002_08
Patent number
US06432955B1

Reaction notes

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