HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Chloride → HCID 86758419, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Chloride | HCID 312 | — |
| Edukt | (4S)-5-(tert-Butoxy)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-oxopentanoic acid | HCID 7017912 | — |
| Edukt | 1,1-Dimethylethyl 1-[(1-amino-6-isoquinolinyl)methyl]-2-oxo-2-(1-piperidinyl)ethyl-carbamate | HCID 22665607 | — |
| Edukt | N-[1-[(1-Amino-6-isoquinolinyl)methyl]-2-oxo-2-(1-piperidinyl)ethyl]-2-[[(3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-yl)sulfonyl]amino]acetamide hydrochloride | HCID 22665631 | — |
| Edukt | HCID 86758418 | HCID 86758418 | — |
| Edukt | HCID 131723437 | HCID 131723437 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | HCID 86758419 | HCID 86758419 | — |
Reaktionsschritte
The procedure described for 5c was used. Deprotection of 5a and coupling with Mtr-Glu(OEt)-OH (prepared from Fmoc-Glu-OtBu, ethanol and Mtr-chloride according to the procedure described for 51a) yielded after purification the title compound (76%) as a mixture of diastereomers (1:1). 1H-NMR 400 MHz (CD3OD) δ: 1.15-2.32 (11H, m), 2.13 (3H, s), 2.40 and 2.42 (3H, 2×s), 2.44 and 2.47 (3H, 2×s), 2.75-4.08 (11H, m), 4.99-5.19 (1H, m), 6.71 and 6.72 (1H, 2×s), 7.16-7.20 (1H, m), 7.51-7.76 (3H, m), 8.30-8.36 (1H, m).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06432955B1 |
| Quelldatensatz | uspto-grants-2002_08 |
| ORD ID | ord-b04bad9254764d8da5538d9ed520f0ad |
| Quellennotiz | uspto-grants-2002_08 |