HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[6-(hydroxymethyl)-1-isoquinolinyl]benzamide → 2,3,4,5-Tetrahydro-1,4-benzoxazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[6-(hydroxymethyl)-1-isoquinolinyl]benzamide | HCID 22665633 | — |
| Reactant | 4-Benzyl-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine | HCID 22665902 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,3,4,5-Tetrahydro-1,4-benzoxazepine | HCID 21882775 | — |
Reaction Steps
10.2 g of 4-benzyl-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine were dissolved in 100 mL of ethanol and hydrogenated for 5 hours at room temperature using 1.2 g of palladium (10% on carbon) as catalyst. Filtration followed by removal of the solvent in vacuo gave 6. 1g of 2,3,4,5-tetrahydro-benzo[f][1,4j]oxazepine as an oil. EI-MS: 149 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06432955B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-b0ede0561d45497982ad6cff868187e6 |
| Source note | uspto-grants-2002_08 |