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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 23043Generated: October 25, 2026

3,5-Dichloroaniline → N-(3,5-dichlorophenyl)alanine isobutyl ester

https://huagongshe.com/reaction/23043

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-DichloroanilineHCID 12281—
ReactantIsobutyl pyruvateHCID 83084—
ProductN-(3,5-dichlorophenyl)alanine isobutyl esterHCID 54461425—

Reaction Steps

Following General Procedure AA above and using 3,5-dichloroaniline (Aldrich) and iso-butyl pyruvate (prepared by following General Procedure AO above), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06849650B2
Source datasetuspto-grants-2005_02
ORD IDord-72ce8be3f194447cb3b1c4857406577e
Source noteuspto-grants-2005_02