Proline benzyl ester hydrochloride → HCID 53943182, compound

HRID 2304323Notes

Reaction equation

HRID 2304323 reaction equation
[CH2:1]([O:3][C:4]([NH:6][C@H:7]([CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)[C:8]([OH:10])=O)=[O:5])[CH3:2].Cl.[CH2:18]([O:25][C:26](=[O:32])[C@@H:27]1[CH2:31][CH2:30][CH2:29][NH:28]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:18]([O:25][C:26]([C@@H:27]1[CH2:31][CH2:30][CH2:29][N:28]1[C:8](=[O:10])[C@H:7]([NH:6][C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:32])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 2733413Proline benzyl ester hydrochlorideHCID 54071643HCID 54071643, compound

Product 1

HCID 53943182HCID 53943182, compoundYield 75.1%

Procedure

Reaction of 1.1 g of (R)-ethoxycarbonylamino-cyclohexyl-acetic acid and 1.16 g of (L)-proline benzyl ester hydrochloride according to the procedure described in example 91b gave 1.50 g (75%) of the title compound as a colorless oil. (+)-APCI-MS: 417 (MH+).

Sources & evidence

ORD record
ord-699dc89ba5a84ca785c8ad6f90fe4c4f
Source dataset
uspto-grants-2002_08
Patent number
US06432955B1

Reaction notes

Loading…