HCID 22958427, compound → HCID 86588695, compound

HRID 2304345Notes

Reaction equation

[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][NH:13]C([C@@H]3CCCN3C(=O)[C@H](NC(=O)C)CC3C=CC(C4C=CC=CC=4)=CC=3)=O)=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[CH2:41]([NH:43][C:44](=[O:66])[NH:45][C@H:46]([CH2:57][C:58]1[CH:63]=[CH:62][C:61]([O:64][CH3:65])=[CH:60][CH:59]=1)[C:47]([N:49]1[CH2:53][CH2:52][CH2:51][C@H:50]1[C:54](O)=[O:55])=[O:48])[CH3:42]>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][NH:13][C:54]([C@@H:50]3[CH2:51][CH2:52][CH2:53][N:49]3[C:47](=[O:48])[C@H:46]([NH:45][C:44]([NH:43][CH2:41][CH3:42])=[O:66])[CH2:57][C:58]3[CH:59]=[CH:60][C:61]([O:64][CH3:65])=[CH:62][CH:63]=3)=[O:55])=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1

Participants

Reactant 2

HCID 22958427HCID 22958427, compound

HCID 865886941-(2-(R)-Acetylamino-3-biphenyl-4yl-propionyl)-pyrrolidin-2-(S)-carboxylic acid (1-amino-isoquinolin-6-ylmethyl)-amide

Product 1

HCID 86588695HCID 86588695, compoundYield 69%

Procedure

Using the procedure described for example 97f 0.190 g of 1-[2-(R)-(3-ethyl-ureido)-3-(4-methoxyphenyl)-propionyl]-pyrrolidine-2-(S)-carboxylic acid was converted into 0.180 g (69%) of the title compound. (+)-APCI-MS: 519(MH+).

Sources & evidence

ORD record: ord-22829c2dacc54e87a1f371a3a0e822b7
Source dataset: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06432955B1

Reaction notes

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