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HRID2304359

反应详情

EQUATION

反应方程式

HRID 2304359 的结构方程式

REACTANTS

反应物

1
结构：COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1.Cl
HCID443868

Barnidipine hydrochloride

C27H30ClN3O6

PRODUCTS

生成物

1
结构：COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1
HCID443869

Barnidipine

C27H29N3O6

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO.O
溶剂HCID22242641

Methanol--water (1/1)

CH6O2

PROCEDURE

实验过程

Barnidipine hydrochloride, TC-5E and HCO-40 were dissolved in water-methanol (1:9). Separately, PEG20000 and POLYOX303 were mixed. Using a fluidized-bed granulator, the latter mixture was sprayed with the above solution. The granules thus prepared were dried, and after addition of lubricant, the composition was compression-molded to provide tablets each measuring 9.0 mm in diameter and 300 mg (barnidipine HCl content: 15 mg).

WORKUP

后处理

  1. additionSeparately, PEG20000 and POLYOX303 were mixed
  2. customThe granules thus prepared
  3. customwere dried
  4. additionafter addition of lubricant