HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Aminopenicillanic acid → Nandrolone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Aminopenicillanic acid | HCID 11082 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | HCID 86758457 | HCID 86758457 | — |
| Product | Nandrolone | HCID 9904 | — |
Reaction Steps
The coupling of the nandrolone phenylmalonate to 6-APA is carried out conventionally after activation with carbonyldiimidazole (CDI). The purification of the conjugate is obtained by extraction in ether in a medium of pH 2 and 8.5 before final recrystallization from a toluene-white petrolatum mixture (see Table 9).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06436649B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-b62ca34af692495fb188b389a1a4e67a |
| Source note | uspto-grants-2002_08 |