Succinic anhydride → HCID 86758459, compound

Participants

Reaction Steps

To a suspension of succinic anhydride (225 mg, 2.25 mmol) in CHCl3 (10 ml) was added under stirring, 4-[N,N-bis(2-chloroethyl)-amino]phenol (compound 6, FIG. 7; 203 mg, 0.75 mmol) followed by triethylamine (75 mg, 0.75 mmol). The mixture was stirred overnight and the solvent evaporated. The crude residue was dissolved in EtOAC/Et2O/H2O and under stirring the pH was adjusted to 3. The organic layer was washed with water, brine, dried (MgSO4), and evaporated. The resulting oil was crystallised from Et2O/hexane and the white solid was filtered off and dried under vacuum to obtain the desired end product (210 mg; yield 83%). Melting point 98-100° C.

Provenance & Evidence