Sulfuric Acid → HCID 54068574, compound

Participants

Reaction Steps

To a solution of isobutylene (34 g) in dichloromethane (100 mL) was added compound 1 (5 g), at 5° C., followed by concentrated sulphuric acid (0.5 mL). The mixture was stirred at ambient temperature for 2 days and poured into saturated sodium bicarbonate solution (200 mL). The aqueous layer was extracted with dichloromethane and the combined organic extracts were dried and evaporated to give an an oil. The oil was chromatographed with 5% ethyl acetate in hexane to give 4-(3-methyl-4-nitro-phenoxy)-benzoic acid tert-butyl ester (compound 2), 2.5 g (42% yield; melting point=81-83° C.).

Provenance & Evidence