Trifluoroacetic acid → Trifluoroacetate

Participants

Reaction Steps

A solution of compound 5 in dichloromethane (5 ml) and trifluoroacetic acid (10 mL) was allowed to stir at ambient temperature for 2 hours. The mixture was evaporated to dryness, azeotroped twice with ethyl acetate to give 4-{4-[bis(2-chloroethyl)-amino]-3-methyl-phenoxy)-benzoic acid (compound 6) as a solid trifluoroacetate salt (1.0 g, 73% yield). Melting point, 91-3° C.

Provenance & Evidence