Trifluoroacetic acid → HCID 22960334, compound

Participants

Reaction Steps

N-(4-{4-[bis-(2-chloroethyl)-amino]-3-methyl-phenoxy}-benzoyl)-L-alanine-tert-butyl ester (400 mg; compound 9) was dissolved in dichloromethane (4 ml) and trifluoroacetic acid (8 ml) was added. The mixture was allowed to stand at ambient temperature for 1 hour, evaporated to dryness and azeotroped twice with ethyl acetate to give the titled compound (compound 10; the drug corresponding with the prodrug of Example 21) as an oil (0.43 g, 52% yield).

Provenance & Evidence