HCID 12019228, compound → HCID 12019230, compound

HRID 2304384Notes

Reaction equation

HRID 2304384 reaction equation
S(=O)(=O)(OC1C=CC2[C@@H]3[C@H]([C@H]4[C@@](CC3)(C)[C@@H](C(=O)NCCC)CC4)CCC=2C=1)N.[S:30](=[O:59])(=[O:58])([O:32][C:33]1[CH:50]=[CH:49][C:48]2[C@@H:47]3[C@H:38]([C@H:39]4[C@@:43]([CH2:45][CH2:46]3)([CH3:44])[C:42]([C:51](=[O:57])[NH:52][C:53]([CH3:56])([CH3:55])[CH3:54])=[CH:41][CH2:40]4)[CH2:37][CH2:36][C:35]=2[CH:34]=1)[NH2:31]>>[S:30](=[O:58])(=[O:59])([O:32][C:33]1[CH:50]=[CH:49][C:48]2[C@@H:47]3[C@H:38]([C@H:39]4[C@@:43]([CH2:45][CH2:46]3)([CH3:44])[C@@H:42]([C:51](=[O:57])[NH:52][C:53]([CH3:54])([CH3:55])[CH3:56])[CH2:41][CH2:40]4)[CH2:37][CH2:36][C:35]=2[CH:34]=1)[NH2:31]

Participants

3

Reactant 2

HCID 12019228HCID 12019228, compoundHCID 12020531HCID 12020531, compound

Product 1

HCID 12019230HCID 12019230, compound

Procedure

In similar manners to those described for the synthesis of compound 7, compound 29e was prepared from compound 11e. FAB-MS m/z 435 (M+H)+; 1H NMR (270 MHz, DMSO-d6) δ 0.59 (s, 3H, CH3), 1.26 (s, 9H, C(CH3)3), 6.89 (s, 1H, NH),6.96 (d, 1H, J=2.3 Hz, ArH), 7.01 (dd, 1H, J=2.3, 8.6 Hz, ArH), 7.34 (d, 1H, J=8.6 Hz, ArH), 7.87 (s, 2H, NH2).

Sources & evidence

ORD record
ord-c55de894d7f14f729f2455fba429816a
Source dataset
uspto-grants-2002_08
Patent number
US06436918B1

Reaction notes

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